| Date | Location | Result | |
| 11/27/21 | Naperville, Ill. | North Central (Ill.) 34, UW-La Crosse 20 | Box score |
| Nov 20, 2021 | Albion, Michigan | UW-La Crosse 64, Albion (Mich.) 17 | Box score |
| 11/13/21 | La Crosse, Wis. | UW-La Crosse 44, UW-Eau Claire 20 | Box score |
| 11/6/21 | Whitewater, Wis. | Wis.-Whitewater 13, UW-La Crosse 7 | Box score |
| 10/30/21 | Stevens Point, Wis. | UW-La Crosse 56, UW-Stevens Point 3 | Box score |
| 10/23/21 | La Crosse, Wis. | UW-La Crosse 44, UW-Stout 38 | Box score |
| 10/16/21 | Platteville, Wis. | UW-La Crosse 24, UW-Platteville 23 | Box score |
| 10/9/21 | La Crosse, Wis. | UW-La Crosse 30, UW-Oshkosh 21 | Box score |
| 10/2/21 | River Falls, Wis. | UW-La Crosse 45, UW-River Falls 23 | Box score |
| 9/18/21 | Allendale, Mich. | Grand Valley State 45, UW-La Crosse 24 | Box score |
| 9/11/21 | La Crosse, Wis. | UW-La Crosse 38, Dubuque (Iowa) 7 | Box score |
| 9/4/21 | Madison, S.D. | UW-La Crosse 42, Dakota State (S.D.) 21 | Box score |